In my home office I have two desktop PC’s, one for my wife and one for me. Both have wireless keyboard and mouse sets and the problem was that when my wife would move her mouse my keyboard and mouse would no longer work (Interference?). For Christmas my wife got me a Bluetooth wireless keyboard and mouse and the problem is now solved! Moral to the story – If you have interference with multiple wireless keyboard and mouse sets switch to Bluetooth, the range is better as well.